Enhanced stability of cis Pro-Pro peptide bond in Pro-Pro-Phe sequence motif
نویسندگان
چکیده
منابع مشابه
Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin.
Investigations determined the mechanism(s) by which Arg-Pro-Pro-Gly-Phe (RPPGF) inhibits thrombin-induced platelet activation. High concentrations of RPPGF inhibit thrombin-induced coagulant activity. RPPGF binds to the active site of thrombin by forming a parallel beta-strand with Ser214-Gly216 and interacts with His57, Asp189, and Ser195 of the catalytic triad. RPPGF competitively inhibits al...
متن کاملAntimicrobially active cycloundecapeptides related to gramicidin S having a novel turn structure with cis D-Phe-Pro peptide bond.
Antimicrobially active cycloundecapeptides related to gramicidin S, cyclo(-Val1-Orn2-Leu3-X4-D-Phe5-Pro6-Val7-Orn8- Leu9-D-Phe10-Pro11-) (X= Leu (1), Ala (2), Orn (3), Lys (4) and Arg (5)), were synthesized. From the CD and NMR studies, 1-5 possess antiparallel -sheet conformation linked by a type II -turn around D-Phe10-Pro11 and a novel turn structure around X4-D-Phe5-Pro6 sequence with cis D...
متن کاملFibrinopeptide A binds Gly-Pro-Arg-Pro.
The tetrapeptide Gly-Pro-Arg-Pro inhibits fibrinogen aggregation, probably by binding to the same sites used during initiation of fibrin formation. The Gly-Pro-Arg-Pro binding sites have not yet been identified. However, their possible sequence and locations have been predicted on the basis of the amino acid pairing hypothesis. One of these predicted sites is on fibrinopeptide A. We report here...
متن کاملStability of pro-gastrin-releasing peptide in serum versus plasma.
BACKGROUND/AIMS Although serum assays for pro-gastrin-releasing peptide (ProGRP) assays have been commercially available in Japan for several years, the stability of ProGRP in serum and plasma has not been well documented. We investigated the stability of ProGRP in serum and plasma with fresh and stored (frozen) specimens, as well as the cause of the observed instability in serum. METHODS/RES...
متن کاملp53: Pro-aging or pro-longevity?
continues to surprise biologists. For nearly a decade, it was thought to be an oncogene [1, 2], only to be subsequently declared a potent tumor suppressor [3, 4]. Initially characterized as a transcriptional activator, we now know p53 is also a transcriptional repressor [5]. And just as it seemed p53 activities were confined to the nucleus, it became apparent that p53 also functioned in the cyt...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2007
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2007.08.039